CADM1 — Cell adhesion molecule 1
CADM1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CADM1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | LAYN+ tissue Treg Immune regulation | BEX3, CHRNA6, EPHX2, FLVCR2, GNG8, IKZF4, LAPTM4B, LAYN +7 more | View in SCUBA |
| Endothelial | Immune Cell Contamination Cell contamination | ANKRD65, CD79B, CLEC1A, IL3RA, JDP2, KAZN, MYH11, MYLK +2 more | View in SCUBA |
| Gamma-delta T cells | Cytotoxic Effector Program cytotoxicity | ADGRG1, ANXA4, CX3CR1, FCGR3A, FGFBP2, FGL2, GNLY, GZMB +14 more | |
| Glial cells | Glial ECM Scaffold ECM remodeling | COL9A3, FBLN2, FGL2, ISLR, ITIH5, LTBP4, MAMDC2, PCSK2 +1 more | View in SCUBA |
About the gene
| Synonyms | BL2, IGSF4, IGSF4A, Necl-2, NECL2, RA175, ST17, SYNCAM, SYNCAM1, TSLC1 |
|---|---|
| Chromosome | 11: 115169218-115504957 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Developmental protein |
| Biological process | Apoptosis, Cell adhesion, Differentiation, Host-virus interaction, Immunity, Spermatogenesis |
Function
Mediates homophilic cell-cell adhesion in a Ca(2+)- independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)- independent manner (By similarity). Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. By interacting with CRTAM and thus promoting the adhesion between CD8+ T- cells and CD8+ dendritic cells, regulates the retention of activated CD8+ T-cell within the draining lymph node (By similarity). Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (By similarity). Interaction with CRTAM promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (By similarity). Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons (By similarity). May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa (By similarity). Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. May contribute to the less invasive phenotypes of lepidic growth tumor cells. (Microbial infection) Induces cell fusion in neuron infected by a neuropathogenic strain of measles. Interacts with measles hemagglutinin to trigger hyperfusogenic F-mediated membrane fusion and presumably transsynaptic cell-to-cell transmission of the virus
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.