PDCL3 — Phosducin like 3
PDCL3 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PDCL3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Smooth muscle cells | Myogenic Cytoskeletal Program Contractility | CARHSP1, GADD45G, ITGB1BP1, MGST2, MYOZ1, NDUFV2, PGAM2, RALY +3 more | View in SCUBA |
About the gene
| Synonyms | VIAF1 |
|---|---|
| Chromosome | 2: 100562993-100576739 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | Chaperone |
| Biological process | Angiogenesis, Apoptosis |
Function
Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation. Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding. Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.