NDUFV2 — NADH:ubiquinone oxidoreductase core subunit V2
NDUFV2 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NDUFV2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | MAF regulatory program Immune regulation | AKAP13, ARID4B, DTHD1, FYN, IKZF3, ISCU, LIMA1, LIMS1 +12 more | View in SCUBA |
| CD8⁺ T cells | OxPhos & Proteasome Mitochondrial & OxPhos | CCT8, ENY2, LSM8, NDUFC2, PPM1G, PSMC5, PSMD7, SAP18 +1 more | View in SCUBA |
| Endothelial | Respiratory Chain Complex Mitochondrial & OxPhos | ATP5MG, CHCHD2, HSBP1, MTCH2, NDUFB11, NDUFS8, SNRPD2, UQCR10 | View in SCUBA |
| Fibroblasts | Proteasome Assembly Housekeeping | ATOX1, C1QBP, DBI, DYNLT1, MANF, MRPL52, PDCD5, PRELID1 +4 more | View in SCUBA |
| Lymphatic endothelial | Protein Quality Control Protein processing & ER | BCAP29, CD99, CDC42, DYNLRB1, GNG5, PDCD6, PFDN5, SKP1 +1 more | View in SCUBA |
| Macrophages | Protein Homeostasis Mixed Housekeeping | ABRACL, ADI1, AP2S1, ATP5F1B, BRK1, CFL1, CHCHD2, CLTA +33 more | View in SCUBA |
| Smooth muscle cells | Myogenic Cytoskeletal Program Contractility | CARHSP1, GADD45G, ITGB1BP1, MGST2, MYOZ1, PDCL3, PGAM2, RALY +3 more | View in SCUBA |
About the gene
| Synonyms | CI-24k |
|---|---|
| Chromosome | 18: 9102630-9134345 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Oxidoreductase, Translocase |
| Biological process | Electron transport, Respiratory chain, Transport |
Function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (Probable). Parts of the peripheral arm of the enzyme, where the electrons from NADH are accepted by flavin mononucleotide (FMN) and then passed along a chain of iron-sulfur clusters by electron tunnelling to the final acceptor ubiquinone (Probable). Contains one iron-sulfur cluster (Probable)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.