GADD45G — Growth arrest and DNA damage inducible gamma
GADD45G belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GADD45G's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Heat-shock response Stress | AHSA1, BAG3, CACYBP, CCDC117, DNAJB6, DYNLL1, FKBP4, HSPA6 +5 more | View in SCUBA |
| CD8⁺ T cells | T Cell Activation TCR Signaling | BIRC3, CRTAM, DUSP5, GEM, HSP90B1, HSPA5, ID3, IL13 +9 more | View in SCUBA |
| Fibroblasts | BMP-ID Stress Response Stress | BHLHE40, CCDC184, CFAP20, FOXC2, GDF15, GDNF, HAS1, HCAR2 +9 more | View in SCUBA |
| Innate lymphoid cells | Cytokine-driven Activation activation | BIRC3, CALR, CD69, DUSP5, ISG15, NCOA7, PPIF, RUNX3 +2 more | View in SCUBA |
| Lymphatic endothelial | Lymphatic Valve Formation Valve formation | CCN1, CCN2, DUSP2, FOXC1, GADD45B, GATA2, HES5, HSPA2 +9 more | View in SCUBA |
| Mucosal-associated invariant T cell | AP-1 Immediate Early Stress | AMD1, BRD2, CITED2, CSKMT, FUS, GADD45B, H2AX, HEXIM1 +17 more | |
| Smooth muscle cells | Myogenic Cytoskeletal Program Contractility | CARHSP1, ITGB1BP1, MGST2, MYOZ1, NDUFV2, PDCL3, PGAM2, RALY +3 more | View in SCUBA |
About the gene
| Synonyms | CR6, DDIT2, GADD45gamma, GRP17 |
|---|---|
| Chromosome | 9: 89605012-89606555 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Developmental protein |
| Biological process | Apoptosis, Differentiation |
Function
Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.