Myogenic Cytoskeletal Program
Gene co-expression module in Smooth muscle cells
| Category | Contractility |
|---|---|
| Genes | 12 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 12 genes have a known function matching the annotation |
Why this annotation
A mixed module: the top hubs are RNA-binding/stability factors (RALY, SNRPN, CARHSP1) while the remaining members are a distinctly myocyte set — MYOZ1 (calsarcin, Z-disc/calcineurin regulator), PGAM2 (muscle phosphoglycerate mutase), TNS1 (tensin-1, dense-body/focal adhesion protein essential for SMC), ITGB1BP1 (ICAP-1, integrin beta1 adhesion signalling) — plus mitochondrial/redox genes (NDUFV2, TSPO, MGST2) and GADD45G. Best interpreted as a low-level smooth-muscle differentiation/contractile-apparatus program co-detected with RNA-binding regulators; coherence is strong but membership of the myogenic genes is moderate, so a composite label is warranted. Neighbors M106 (PLN, CALM2) reinforce the presence of a contractile/calcium axis in this neighborhood.
Genes
CARHSP1, GADD45G, ITGB1BP1, MGST2, MYOZ1, NDUFV2, PDCL3, PGAM2, RALY, SNRPN, TNS1, TSPO
Most correlated modules
- Oxidative Muscle Metabolism · correlation 0.89
- Basal Maintenance Genes · correlation 0.85
- Vascular SMC Identity · correlation 0.84
- OXPHOS Complex I · correlation 0.82
- Ubiquitous Housekeeping Transcripts · correlation 0.81
- Basal Metabolic Housekeeping · correlation 0.81
- Glucocorticoid Metallothionein Response · correlation 0.80
- Calcium Handling Contractile · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.