PDP1 — Pyruvate dehydrogenase phosphatase catalytic subunit 1
PDP1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PDP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Immediate early activation TCR/AP1/NFKb pathway | ALG13, AREG, BCAS2, C9orf72, CXCR4, FAM222A, HIP1R, NR4A2 +18 more | View in SCUBA |
About the gene
| Synonyms | PDH, PDP, PPM2A, PPM2C |
|---|---|
| Chromosome | 8: 93857807-93926068 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Hydrolase, Protein phosphatase |
Function
Mitochondrial enzyme that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (PDC), thereby stimulating the conversion of pyruvate into acetyl-CoA.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.