PGAP4 — Post-GPI attachment to proteins GalNAc transferase 4
PGAP4 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PGAP4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Hematopoietic progenitor cells | HSC Stemness Program Stemness | ADRA2A, ALDH1A1, ATP6V0A2, CPPED1, DEPTOR, FCER1A, FREM1, PBX1 +4 more |
About the gene
| Synonyms | C9orf125, MGC12992, TMEM246 |
|---|---|
| Chromosome | 9: 101473170-101533537 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins |
| Molecular function | Transferase |
Function
Golgi-resident glycosylphosphatidylinositol (GPI)-N- acetylgalactosamine transferase that catalyzes the N-acetyl-beta-D- galactosamine transfer from an UDP-N-acetyl-alpha-D-galactosamine to the 4-OH-position of the first mannose of the glycosylphosphatidylinositol (GPI) of a GPI-anchored protein (GPI-AP). This modification occurs after the fatty acid remodeling step of the GPI-anchor maturation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.