HSC Stemness Program
Gene co-expression module in Hematopoietic progenitor cells
| Category | Stemness |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes PBX1 (HSC self-renewal transcription factor), ALDH1A1 (primitive HSC marker via retinoic acid metabolism), and DEPTOR (mTOR inhibitor maintaining stemness) anchor this module to a primitive hematopoietic progenitor/stemness program. Supporting genes include sialylation enzymes (ST8SIA6, ST6GAL2) and FCER1A suggesting a basophil/mast cell progenitor bias. The uniform low expression and core coherence are consistent with a rare primitive progenitor state. Neighbor modules M39 and M55 are megakaryocyte/platelet programs, suggesting this batch captures differentiation trajectories from primitive progenitors through lineage commitment.
Genes
ADRA2A, ALDH1A1, ATP6V0A2, CPPED1, DEPTOR, FCER1A, FREM1, PBX1, PGAP4, PRKG2, ST6GAL2, ST8SIA6, TESPA1
Most correlated modules
- Oxidative Stress Survival · correlation 0.88
- Erythro-Megakaryocytic Development · correlation 0.85
- Erythroid Progenitor Program · correlation 0.84
- Erythroid Maturation Signaling · correlation 0.79
- HSC Progenitor Proliferation · correlation 0.73
- Erythroid Differentiation · correlation 0.72
- Replication Stress Response · correlation 0.70
- Mast Cell Progenitor · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.