CPPED1 — Calcineurin like phosphoesterase domain containing 1
CPPED1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CPPED1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Hematopoietic progenitor cells | HSC Stemness Program Stemness | ADRA2A, ALDH1A1, ATP6V0A2, DEPTOR, FCER1A, FREM1, PBX1, PGAP4 +4 more | |
| Neutrophils | PI3K Migration Signaling Migration & adhesion | CREB5, CYTIP, PELI1, PTEN, RASSF3, SEMA4D, SH2D3C, SIRPB2 +3 more |
About the gene
| Synonyms | CSTP1, FLJ11151 |
|---|---|
| Chromosome | 16: 12659799-12803887 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Hydrolase |
Function
Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.