PIK3C3 — Phosphatidylinositol 3-kinase catalytic subunit type 3
PIK3C3 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PIK3C3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Membrane Trafficking Protein processing & ER | B4GALT1, BTF3L4, CELF1, CLTC, CSNK1G3, CTBS, DERL2, DYNC1LI2 +23 more | View in SCUBA |
About the gene
| Synonyms | hVps34, Vps34 |
|---|---|
| Chromosome | 18: 41955234-42087830 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Kinase, Transferase |
| Biological process | Autophagy, Cell cycle, Cell division, Lipid metabolism |
Function
Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding. Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2. Involved in the transport of lysosomal enzyme precursors to lysosomes (By similarity). Required for transport from early to late endosomes (By similarity). (Microbial infection) Kinase activity is required for SARS coronavirus-2/SARS-CoV-2 replication
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.