SCUBA

B4GALT1 — Beta-1,4-galactosyltransferase 1

B4GALT1 belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

B4GALT1's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsOxidative/ER stress
Stress
ASAH1, ATP6V0D1, FAM210A, FOSL2, GEM, GZF1, HIC1, MAFG +6 moreView in SCUBA
CD4⁺ T cellsMembrane Trafficking
Protein processing & ER
BTF3L4, CELF1, CLTC, CSNK1G3, CTBS, DERL2, DYNC1LI2, EMC9 +23 moreView in SCUBA
FibroblastsER Stress UPR
Stress
ARF4, BTG3, BZW1, CYCS, EFHD2, ELOC, LDHA, LITAF +6 moreView in SCUBA
Gamma-delta T cellsMAPK Kinase Signaling
TCR Signaling
ARIH1, BRAF, CDK16, CHD1, DYRK1A, GNA13, KDM2A, MAP3K2 +8 more
Goblet cellsInflammatory goblet response
Immune function
ANXA1, CAPN8, CEACAM6, DST, KRT20, LYPD8, MUC13, MXD1 +8 moreView in SCUBA
Lymphatic endothelialNRF2 Oxidative Stress
Stress
CTTNBP2NL, DDX21, DRAM1, GCH1, HNRNPF, MSN, NFE2L2, PDXDC1 +11 moreView in SCUBA
MacrophagesNF-κB AP-1 Signaling
Inflammatory
ABL2, AGAP3, ARL8B, ATP1B3, ATP6V1H, C5AR2, CDKN1A, CERT1 +21 moreView in SCUBA
MonocytesWnt/AP-1 Activation
Inflammatory
BZW1, CHD1, CTNNB1, ETF1, FOSL2, GABARAPL1, GPCPD1, PNPLA8 +2 moreView in SCUBA
Mucosal-associated invariant T cellRUNX3 Tissue Identity
T cell maturation
CD44, CDK17, CHD1, CYLD, EML4, EP300, GPBP1, KMT2E +10 more

About the gene

Synonymsbeta4Gal-T1, GGTB2
Chromosome9: 33104082-33167356
Predicted locationMembrane
Essential geneNo
Protein classDisease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted membrane proteins
Molecular functionGlycosyltransferase, Transferase
Biological processLipid metabolism

Function

The Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. The cell surface form functions as a recognition molecule during a variety of cell to cell and cell to matrix interactions, as those occurring during development and egg fertilization, by binding to specific oligosaccharide ligands on opposing cells or in the extracellular matrix

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.