CLTC — Clathrin heavy chain
CLTC belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CLTC's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Membrane Trafficking Protein processing & ER | B4GALT1, BTF3L4, CELF1, CSNK1G3, CTBS, DERL2, DYNC1LI2, EMC9 +23 more | View in SCUBA |
| Fibroblasts | Collagen ECM Production ECM production | AEBP1, ANGPTL2, ANTXR1, CERCAM, COL1A1, COL1A2, COL3A1, COL5A1 +12 more | View in SCUBA |
| Gamma-delta T cells | Chromatin Epigenetic Regulation DNA/chromatin regulation | ACIN1, ASH1L, BDP1, BLTP1, EPS15, EXOC2, FAM120B, GATAD2B +24 more | |
| Lymphatic endothelial | Innate Immune Activation Immune regulation | CD46, CRIM1, EIF2AK2, ENSA, FEZ2, GSN, PDLIM3, PON2 +9 more | View in SCUBA |
| Macrophages | Myeloid Innate Signaling Innate immunity | ADCY7, ARHGAP18, BMP2K, C3AR1, C6orf62, CD46, CD84, CNEP1R1 +34 more | View in SCUBA |
| Mucosal-associated invariant T cell | Histone Modification DNA/chromatin regulation | ANKRD17, ARHGEF6, ASH1L, FAM120B, KDM4C, NRDC, PCM1, RELCH +3 more |
About the gene
| Synonyms | CLTCL2, Hc |
|---|---|
| Chromosome | 17: 59619684-59696956 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Disease related genes, Essential proteins, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters |
| Biological process | Autophagy, Cell cycle, Cell division, Mitosis |
Function
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans- Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. Plays a role in early autophagosome formation. Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.