Membrane Trafficking
Gene co-expression module in CD4⁺ T cells
| Category | Protein processing & ER |
|---|---|
| Genes | 32 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 32 genes have a known function matching the annotation |
Why this annotation
Broad module of intracellular trafficking, glycosylation and metabolism: CLTC (clathrin heavy chain), GOSR2 (Golgi SNARE), PIK3C3 (autophagy/vesicle), GPHN (gephyrin), GPI (glycolysis), B4GALT1/CTBS/ST8SIA4 (glycosylation), UBE2J2 (ERAD), HIGD1A (hypoxia/mito), PIEZO1 (mechanosensor). No coherent immune program; dominated by membrane trafficking and glycosylation housekeeping machinery with uniform expression.
Genes
B4GALT1, BTF3L4, CELF1, CLTC, CSNK1G3, CTBS, DERL2, DYNC1LI2, EMC9, FAM174B, GOSR2, GPHN, GPI, GPR137B, HIGD1A, HLF, KMT2B, MAPK6, MED13, MR1, PBDC1, PIEZO1, PIK3C3, RFK, SF3A3, ST8SIA4, SVBP, TACC1, TATDN1, TERF1, THAP12, UBE2J2
Most correlated modules
- mRNA Processing · correlation 0.94
- Vesicle Trafficking Signaling · correlation 0.84
- CD4 Lineage Identity · correlation 0.83
- T-cell quiescence regulation · correlation 0.80
- Mitochondrial Translation · correlation 0.80
- Lipid Metabolism · correlation 0.78
- Leukocyte Motility · correlation 0.77
- Protein/ER secretory machinery · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.