PILRA — Paired immunoglobin like type 2 receptor alpha
PILRA belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PILRA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Fc Receptor Phagocytosis Lysosomal & pahgocytosis | ANXA6, C1orf162, CD37, FCGR1A, FCGR3A, FPR1, GCA, HNMT +10 more | View in SCUBA |
| Monocytes | Myeloid Innate Receptor Signaling Innate immunity | CYTIP, HCK, JPT1, LILRA5, LILRB2, MYD88, PAG1, SERPINA1 | View in SCUBA |
| Neutrophils | NF-κB Inflammatory Transcription Inflammatory | BID, C9orf72, DENND5A, ELL2, ETF1, N4BP1, NFE2L2, NFKB1 +10 more |
About the gene
| Synonyms | FDF03 |
|---|---|
| Chromosome | 7: 100367530-100400096 |
| Predicted location | Membrane, Secreted |
| Essential gene | No |
| Protein class | Predicted membrane proteins, Predicted secreted proteins |
| Molecular function | Receptor |
| Biological process | Host-virus interaction |
Function
Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP. (Microbial infection) Acts as an entry co-receptor for herpes simplex virus 1
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.