CD58 — CD58 molecule
CD58 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CD58's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | NF-kB regulation TCR/AP1/NFKb pathway | ARIH2, CYLD, DAD1, DERL1, EED, ELOVL5, NFAT5, OTULIN +9 more | View in SCUBA |
| Endothelial | EC Inflammatory Activation Inflammation | ARHGAP4, ARHGEF2, ARL15, ATP13A3, CAPZA2, GFOD1, GJA4, HABP4 +12 more | View in SCUBA |
| Gamma-delta T cells | Actin-based Motility Cytoskeletal | APBB1IP, COMMD7, CORO1B, CTSD, EVL, FDFT1, HMOX2, OSTF1 +13 more | |
| Macrophages | Hypoxia-driven Activation Inflammatory | ACVR1B, ADAM10, ADAM9, ALCAM, ANO6, B3GNT2, BTG1, C5AR1 +33 more | View in SCUBA |
About the gene
| Synonyms | LFA3 |
|---|---|
| Chromosome | 1: 116514534-116571039 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | CD markers, Human disease related genes, Predicted membrane proteins |
Function
Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.