EC Inflammatory Activation
Gene co-expression module in Endothelial
| Category | Inflammation |
|---|---|
| Genes | 21 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 21 genes have a known function matching the annotation |
Why this annotation
Hub genes include JAG2 (Notch ligand), LRP6 (Wnt co-receptor), ARHGAP4/ARHGEF2 (Rho GTPase regulators), GJA4 (arterial connexin), MECOM and SOX13 (vascular transcription factors), and CD58 (adhesion). The module is upregulated in inflammation and captures a broad endothelial activation/signaling program involving Notch, Wnt, and Rho GTPase pathways. CAPZA2 and ARHGEF2 also implicate cytoskeletal remodeling downstream of these signals.
Genes
ARHGAP4, ARHGEF2, ARL15, ATP13A3, CAPZA2, CD58, GFOD1, GJA4, HABP4, JAG2, LPCAT2, LRP6, MECOM, MPPED2, MXRA7, PLCL1, S100A4, SLC48A1, SOX13, SRP14, TM6SF1
Most correlated modules
- Inflammatory Angiogenesis · correlation 0.91
- Cytoskeletal Scaffolding · correlation 0.90
- Vascular Homeostasis · correlation 0.89
- Arterial EC Identity · correlation 0.87
- EC Barrier Integrity · correlation 0.87
- Arterial EC Identity · correlation 0.86
- Inflammatory Angiogenic Activation · correlation 0.84
- Endothelial Quiescence · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.