SCUBA

ATP13A3 — ATPase 13A3

ATP13A3 belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ATP13A3's module in each cell type

Cell typeModuleShares the module with
CD4⁺ T cellsRegulatory T cell
Immune regulation
ACTA2, APOLD1, CARD16, CD27, CD79B, DNAH8, FAM184A, HS3ST3B1 +7 moreView in SCUBA
EndothelialEC Inflammatory Activation
Inflammation
ARHGAP4, ARHGEF2, ARL15, CAPZA2, CD58, GFOD1, GJA4, HABP4 +12 moreView in SCUBA
FibroblastsAP-1 Inflammatory Stress
Inflammatory
ALAS1, BATF3, CCDC71L, DDX21, FOSL1, NINJ1, PANX1, SBNO2 +1 moreView in SCUBA
Gamma-delta T cellsTranscriptional Coactivation
DNA/chromatin regulation
ATN1, ATP1A1, CREBBP, FAM76B, GAK, GALNT1, MDM2, PDS5A +12 more
Lymphatic endothelialStress Kinase Signaling
Stress
CLN8, CREBRF, CYLD, DYRK3, INO80D, IPO5, KLHL21, KMT2A +6 moreView in SCUBA
MacrophagesMonocyte Lipid Metabolism
Lipid metabolism
CEP170, CHIC2, COQ10B, CSGALNACT2, ENOSF1, HIPK2, HMGXB3, KIF13A +14 moreView in SCUBA
MonocytesTNF-driven Activation
Inflammatory
CD44, DCUN1D3, DSE, GK, IVNS1ABP, LAMB3, LITAF, POMP +3 moreView in SCUBA
NeutrophilsNF-κB Signaling
Inflammatory
BMP6, DOCK4, DSE, FLT1, HIVEP2, IRAK2, KIFC3, MAML2 +2 more
PericytesArterial Pericyte Identity
Developmental
BMX, FBLN2, GJA5, KCTD12, LTC4S, PLLP, SEMA3G, TMEM100 +1 moreView in SCUBA

About the gene

SynonymsAFURS1
Chromosome3: 194402672-194498364
Predicted locationMembrane
Essential geneNo
Protein classDisease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted membrane proteins
Molecular functionTranslocase

Function

ATP-driven pump involved in endocytosis-dependent polyamine transport. Uses ATP as an energy source to transfer polyamine precursor putrescine from the endosomal compartment to the cytosol

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.