ARHGAP4 — Rho GTPase activating protein 4
ARHGAP4 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ARHGAP4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | EC Inflammatory Activation Inflammation | ARHGEF2, ARL15, ATP13A3, CAPZA2, CD58, GFOD1, GJA4, HABP4 +12 more | View in SCUBA |
| Gamma-delta T cells | Immune Synapse Cytoskeleton Cytoskeletal | ARHGAP45, ATP2A3, CD48, DDOST, ICAM3, IL32, LAPTM5, LTB4R2 +8 more | |
| Macrophages | Endosomal Membrane Trafficking Vesicular traficking | A2M, AP1B1, ARHGEF6, ATG4C, B3GNT7, CRTAP, ETV5, FYB1 +20 more | View in SCUBA |
About the gene
| Synonyms | C1, KIAA0131, p115, RhoGAP4, SrGAP4 |
|---|---|
| Chromosome | X: 153907367-153934999 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | GTPase activation |
Function
Inhibitory effect on stress fiber organization. May down- regulate Rho-like GTPase in hematopoietic cells
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.