PPIL1 — Peptidylprolyl isomerase like 1
PPIL1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PPIL1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Glycolysis Activation Housekeeping | ATP5F1B, BSG, CCT7, COPE, FKBP3, GAPDH, ISOC2, KDELR2 +8 more | View in SCUBA |
About the gene
| Synonyms | CYPL1 |
|---|---|
| Chromosome | 6: 36854827-36874803 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Enzymes, Essential proteins, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Isomerase, Rotamase |
| Biological process | mRNA processing, mRNA splicing |
Function
Involved in pre-mRNA splicing as component of the spliceosome. PPIases accelerate the folding of proteins. Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Catalyzes prolyl peptide bond isomerization in CDC40/PRP17. Plays an important role in embryonic brain development; this function is independent of its isomerase activity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.