Glycolysis Activation
Gene co-expression module in Endothelial
| Category | Housekeeping |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 13 of 17 genes have a known function matching the annotation |
Why this annotation
Top hub genes PGAM1, TPI1, PKM, and GAPDH are canonical glycolytic enzymes, indicating a glycolysis program. PSMA4, PSMB4, PSMA7 are proteasome alpha/beta subunits. KDELR2 and COPE link to ER/Golgi (shared with M13 neighbor). P4HB is protein disulfide isomerase (ER folding). BSG (CD147) is a glycolytic chaperone for MCT transporters. CCT7 is a chaperonin. The co-expression of glycolysis and proteasome subunits suggests a metabolic activation state in inflamed endothelium. Upregulated significantly in UC and CD inflammation, reversed in remission.
Genes
ATP5F1B, BSG, CCT7, COPE, FKBP3, GAPDH, ISOC2, KDELR2, P4HB, PGAM1, PKM, PPIL1, PSMA4, PSMA7, PSMB4, TPI1, UBE2L3
Most correlated modules
- ER-Golgi Trafficking · correlation 0.96
- ER Protein Processing · correlation 0.93
- Proteasomal Degradation · correlation 0.93
- Mitochondrial OxPhos · correlation 0.93
- mRNA Splicing Stress · correlation 0.93
- UPR / ER Stress · correlation 0.92
- Respiratory Chain Complex · correlation 0.91
- Mitochondrial OxPhos · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.