FKBP3 — FKBP prolyl isomerase 3
FKBP3 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FKBP3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Mitochondrial Translation Mitochondrial & OxPhos | ARF5, CBX6, CCDC124, CISD3, DCTN2, DDA1, EIF4E2, GID8 +17 more | View in SCUBA |
| Endothelial | Glycolysis Activation Housekeeping | ATP5F1B, BSG, CCT7, COPE, GAPDH, ISOC2, KDELR2, P4HB +8 more | View in SCUBA |
| Innate lymphoid cells | RNA Splicing Processing RNA processing & translation | ATP5F1C, CHMP2A, CHMP4A, CYBA, DSTN, DYNC1I2, DYNLRB1, LSM3 +16 more | View in SCUBA |
| Macrophages | Spliceosomal snRNP Cell cycle | ANAPC11, BANF1, CCDC25, CCT8, ERH, FIBP, GLRX5, IER3IP1 +30 more | View in SCUBA |
About the gene
| Synonyms | FKBP-25, FKBP25 |
|---|---|
| Chromosome | 14: 45115599-45135319 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Isomerase, Rotamase |
Function
FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.