KDELR2 — KDEL endoplasmic reticulum protein retention receptor 2

KDELR2 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

KDELR2's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	ER protein processing Protein processing & ER	EIF6, PDIA6, PSMC3, PSMC4, SDF2L1, SPCS2, UBE2L3	View in SCUBA
Endothelial	Glycolysis Activation Housekeeping	ATP5F1B, BSG, CCT7, COPE, FKBP3, GAPDH, ISOC2, P4HB +8 more	View in SCUBA
Fibroblasts	ER Protein Processing Vesicular traficking	ARPC2, ENO1, GTF3C6, LMAN1, OSTC, P4HB, PRDX4, PSMC4 +5 more	View in SCUBA
Gamma-delta T cells	T Cell Exhaustion Exhaustion	ACADVL, ACSS1, ADSS2, B4GALT3, CDK11A, CHP1, CNOT2, CNOT8 +20 more
Goblet cells	Mucin Folding Machinery Mucus production & secretion	AGR2, MYDGF, OSTC, PPIB, SEC11C, SEC61B, SEC61G, SSR3	View in SCUBA
Macrophages	Glycolytic Metabolism Housekeeping	ARL1, ARPC5, ATP5PB, ATRAID, C4orf3, CALM1, CAPZA2, CHMP5 +30 more	View in SCUBA
Pericytes	ER Protein Folding Stress	AP2S1, CALU, DYNLT1, IKBIP, MYDGF, OSTC, P4HB, PPIB +1 more	View in SCUBA
Smooth muscle cells	ER-Golgi Secretory Pathway Protein processing & ER	BZW1, CCT3, COL15A1, GPC6, IFT57, LRPAP1, NFATC4, PAM +4 more	View in SCUBA

About the gene

Synonyms	ELP-1, ERD2.2
Chromosome	7: 6445953-6484190
Predicted location	Membrane
Essential gene	No
Protein class	Disease related genes, Human disease related genes, Predicted membrane proteins
Molecular function	Receptor
Biological process	ER-Golgi transport, Protein transport, Transport

Function

Membrane receptor that binds the K-D-E-L sequence motif in the C-terminal part of endoplasmic reticulum resident proteins and maintains their localization in that compartment by participating to their vesicle-mediated recycling back from the Golgi. Binding is pH dependent, and is optimal at pH 5-5.4 (By similarity).

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.