CCT7 — Chaperonin containing TCP1 subunit 7
CCT7 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CCT7's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Nucleotide Metabolism Biosynthesis Mitochondrial & OxPhos | ATIC, ATP5MC1, C1QBP, DCTPP1, EBNA1BP2, EEF1E1, EIF5A, GADD45GIP1 +13 more | View in SCUBA |
| CD4⁺ T cells | Nucleotide biosynthesis Housekeeping | COPRS, DCTPP1, MRPL12, MRPL4, NHP2, NME1, PPA1, PRDX4 +6 more | View in SCUBA |
| CD8⁺ T cells | Proteostasis Translation Protein processing & ER | BZW1, CCT5, EIF2S2, HNRNPC, HNRNPM, MDH1, PCBP1, PSMD13 +3 more | View in SCUBA |
| Endothelial | Glycolysis Activation Housekeeping | ATP5F1B, BSG, COPE, FKBP3, GAPDH, ISOC2, KDELR2, P4HB +8 more | View in SCUBA |
| Gamma-delta T cells | Chaperone Protein Folding Protein processing & ER | AAMP, AHCYL1, CCT8, CHMP5, COX17, DPY30, EIF2S2, GHITM +16 more | |
| Innate lymphoid cells | ILC1 Cytoskeletal Metabolic Cytoskeleton & motility | ATP5F1B, ATXN10, CD82, DNPH1, GADD45GIP1, HMGA1, MEA1, MTCH2 +14 more | View in SCUBA |
| Macrophages | Mitochondrial Biogenesis Mitochondrial & OxPhos | AIMP1, ATP5F1D, ATP5MC1, C1QBP, CCT2, CCT3, CHCHD1, CHCHD5 +38 more | View in SCUBA |
About the gene
| Synonyms | Ccth, Nip7-1 |
|---|---|
| Chromosome | 2: 73233420-73253021 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Chaperone, Hydrolase |
Function
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.