PPP2R5B — Protein phosphatase 2 regulatory subunit B'beta
PPP2R5B belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PPP2R5B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | IFN-gamma Response Inflammation | BATF2, CBR3, CD274, CIITA, ETV7, FAM83A, GBP4, ICAM1 +8 more | View in SCUBA |
About the gene
| Synonyms | B56B, B56beta, FLJ35411, PR61B |
|---|---|
| Chromosome | 11: 64917553-64934475 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
Function
As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.