GBP4 — Guanylate binding protein 4

GBP4 belongs to a gene co-expression module in 12 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

GBP4's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Type I Interferon Anti-viral	GBP2, IRF9, ISG15, ISG20, LY6E, MNDA, MX1, MX2 +9 more	View in SCUBA
CD4⁺ T cells	Interferon Response Anti-viral	APOL6, ARL6IP5, BAX, GBP5, IFI16, IQGAP1, IRF9, MYH9 +4 more	View in SCUBA
Endothelial	IFN-gamma Response Inflammation	APOL2, APOL6, BATF2, CARD16, CASP1, CD40, CXCL10, CXCL11 +18 more	View in SCUBA
Enterocytes	IFN-gamma STAT1 signaling Inflammation	C2, ENSG00000283782, HLA-E, LAP3, NLRC5, PARP8, STAT1, TAP1 +1 more	View in SCUBA
Fibroblasts	IFN-γ MHC-II Response Inflammatory	CALHM6, CD74, CXCL11, CXCL9, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DRA +3 more	View in SCUBA
Gamma-delta T cells	ER Glycoprotein Quality Control Protein processing & ER	APOL2, BAG6, CALR, ELP3, GBP1, GBP2, HEXB, HSP90B1 +9 more
Hematopoietic progenitor cells	Megakaryocyte IFN-primed Inflammatory	COL24A1, ELK3, GUCY1A1, HLA-E, IFI16, IQGAP2, MAML2, MYO5C +2 more
Innate lymphoid cells	IFN-gamma Response Inflammation	APOL6, B3GALT5, DST, ELK3, GBP2, GBP5, GOLGA8A, HLA-DRB1 +16 more	View in SCUBA
Macrophages	Innate Antiviral Sensing Innate immunity	ADA2, ADPRH, ALDH9A1, APOBEC3C, BST2, C2, CAT, CD4 +26 more	View in SCUBA
Monocytes	IFN-gamma Response Antiviral	APOL2, APOL6, CXCL10, ETV7, GBP1, GBP5, IFIH1, ISG15 +6 more	View in SCUBA
Mucosal-associated invariant T cell	Type I Interferon Inflammation	DDX60, DDX60L, DTX3L, EIF2AK2, EPSTI1, GBP2, HERC5, IFI16 +18 more
Smooth muscle cells	Type I Interferon Inflammation	BST2, HLA-F, IFI6, IFIT2, IFITM1, ISG15, LY6E, PSMB8 +3 more	View in SCUBA

About the gene

Synonyms	Mpa2
Chromosome	1: 89181144-89198942
Predicted location	Intracellular
Essential gene	No
Protein class	Plasma proteins, Predicted intracellular proteins
Molecular function	Hydrolase
Biological process	Immunity, Innate immunity

Function

Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (By similarity). Negatively regulates the antiviral response by inhibiting activation of IRF7 transcription factor (By similarity)

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.