CBR3 — Carbonyl reductase 3
CBR3 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CBR3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Naive T cell T cell development | AIF1, AK5, APBA2, BEND5, BEX2, C1orf162, CYSLTR1, ENC1 +21 more | View in SCUBA |
| Fibroblasts | TGF-beta Response ECM remodeling | C1orf21, CNRIP1, DOK5, FREM1, GUSB, HTRA1, LRRN4CL, NR3C1 +7 more | View in SCUBA |
About the gene
| Synonyms | SDR21C2 |
|---|---|
| Chromosome | 21: 36135079-36146562 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Oxidoreductase |
Function
Catalyzes the NADPH-dependent reduction of carbonyl compounds to their corresponding alcohols. Has low NADPH- dependent oxidoreductase activity. Acts on several orthoquinones, acts as well on non-quinone compounds, such as isatin or on the anticancer drug oracin. Best substrates for CBR3 is 1,2- naphthoquinone, hence could play a role in protection against cytotoxicity of exogenous quinones. Exerts activity toward ortho-quinones but not paraquinones. No endogenous substrate for CBR3 except isatin has been identified.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.