BATF2 — Basic leucine zipper ATF-like transcription factor 2
BATF2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BATF2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | IFN-gamma Response Inflammation | APOL2, APOL6, CARD16, CASP1, CD40, CXCL10, CXCL11, CXCL9 +18 more | View in SCUBA |
| Fibroblasts | Type I Interferon Inflammatory | APOL6, CXCL10, GBP1, IFI44L, IFIT2, IFIT3, ISG15, MX1 +6 more | View in SCUBA |
About the gene
| Synonyms | MGC20410 |
|---|---|
| Chromosome | 11: 64987945-64997018 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding |
| Biological process | Differentiation, Transcription, Transcription regulation |
Function
AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, participates in the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes (By similarity). Selectively suppresses CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CCN1 and inhibits CCN1-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma. Possibly acts by interfering with AP-1 binding to CCN1 promoter
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.