IFN-gamma Response
Gene co-expression module in Colonocytes
| Category | Inflammation |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 11 of 17 genes have a known function matching the annotation |
Why this annotation
This module is strongly enriched in inf_colono and significantly upregulated in both UC and CD inflammation, with reversal at UC remission. Hub genes are canonical interferon-gamma response genes: GBP4 (guanylate-binding protein, IFN-gamma induced), IDO1 (indoleamine 2,3-dioxygenase, IFN-gamma target, tryptophan catabolism), ICAM1 (IFN-gamma-induced adhesion molecule), ETV7 (IFN-stimulated transcription factor), IL18BP (IL-18 binding protein, IFN-gamma induced), PML (promyelocytic leukemia, IFN target), TRAFD1 (TRAF domain-containing, IFN signaling), CD274 (PD-L1, IFN-gamma induced), BATF2 (IFN-gamma-driven transcription factor), CIITA (MHC class II transactivator, IFN-gamma target). This is a tightly coherent IFN-gamma response module in inflamed colonocytes, distinct from the broader innate immune modules in the batch.
Genes
Most correlated modules
- Hypoxia-Inflammatory Reprogramming · correlation 0.88
- IFN-γ Antiviral Response · correlation 0.84
- Wound Regenerative Response · correlation 0.83
- MHC II Antigen Presentation · correlation 0.80
- Oxidative Inflammatory Remodeling · correlation 0.77
- Basement Membrane Remodeling · correlation 0.77
- Epithelial Innate Immunity · correlation 0.77
- Inflammatory Stress Response · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.