ICAM1 — Intercellular adhesion molecule 1

ICAM1 belongs to a gene co-expression module in 14 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ICAM1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	NF-kB activation/survival BCR/AP1/NFKb pathway	ARL4C, BCL2A1, CCR7, DDX21, GNG2, IRF2BPL, LMNA, NAMPT +9 more	View in SCUBA
CD4⁺ T cells	NF-kB activation TCR/AP1/NFKb pathway	ADRA2B, CD83, CHD4, CYB5D1, DUSP2, EGR2, EGR3, EGR4 +9 more	View in SCUBA
Endothelial	NF-κB Early Response Inflammation	BCL3, BHLHE40, INSIG1, ITPKC, KLF10, LDLR, MYADM, RND1 +3 more	View in SCUBA
Fibroblasts	Proteotoxic Stress Survival Stress	ARL5B, BAG3, DNAJA4, PPIF, PPP1R15B, SLC25A25, TIPARP, TNFRSF10D	View in SCUBA
Gamma-delta T cells	XCL1/XCL2 Cytotoxic Activation cytotoxicity	BCL2A1, CCL3L3, CCL4L2, FASLG, IRF8, PLEKHO2, RILPL2, SNX18 +6 more
Glial cells	NF-κB/IFN Inflammatory Inflammation	BIRC3, CTSS, CXCL10, CXCL2, CXCL9, FDCSP, HAPLN3, PTX3 +4 more	View in SCUBA
Innate lymphoid cells	NF-κB Inflammatory Activation Inflammation	CDKN1A, CSRNP1, DUSP1, DUSP2, DUSP6, ELL2, EZR, FOS +26 more	View in SCUBA
Lymphatic endothelial	NF-κB Negative Feedback Inflammation	BMP2, C2CD4B, IRF8, KLF6, MAFF, NFIL3, NFKBIA, PRNP +4 more	View in SCUBA
Macrophages	NF-κB Activation Inflammatory	BCL3, BLOC1S6, CD83, CFLAR, CHMP1B, CNOT2, CSRNP1, CYLD +33 more	View in SCUBA
Monocytes	NF-κB Signaling Inflammatory	BIRC3, ERN1, G0S2, IER3, IRAK2, NFKB1, PDE4B, PNRC1 +4 more	View in SCUBA
Mucosal-associated invariant T cell	NF-κB Effector Activation Inflammation	ADGRE5, BCL2A1, CCL20, CCL3, CCL3L3, CCL4, CCL4L2, DUSP10 +10 more
Natural Killer cells	Autophagy-Inflammation Stress Stress	BCL2A1, DDIT3, IFFO2, JMJD6, KLF10, MAP1LC3B, MKNK2, SIK3 +3 more	View in SCUBA
Neutrophils	Neutrophil Adhesion Signaling Migration & adhesion	B3GNT5, ETS2, GK, LCP2, PDE4B, SKIL, ZNF267
Pericytes	NF-κB Inflammatory Response Inflammatory	ABL2, ADAMTS9, ARL4A, BCL3, BHLHE40, FOSL2, KLF10, PIM3 +3 more	View in SCUBA

About the gene

Synonyms	BB2, CD54
Chromosome	19: 10271093-10286615
Predicted location	Intracellular, Membrane
Essential gene	No
Protein class	Cancer-related genes, Candidate cardiovascular disease genes, CD markers, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Molecular function	Host cell receptor for virus entry, Receptor
Biological process	Cell adhesion, Host-virus interaction

Function

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. (Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins. (Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins. (Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T- lymphocytes and NK cell

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.