PRXL2A — Peroxiredoxin like 2A
PRXL2A belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PRXL2A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Microvillus actin cytoskeleton Cytoskeletal | CYB5A, HSD17B11, SCIN, SMPD3, TDP2, VIL1 | View in SCUBA |
| Lymphatic endothelial | Septin Cytoskeleton Cytoskeletal | AHNAK, DSP, EFCAB14, GOLGB1, SEPTIN10, SEPTIN2, SEPTIN7, TPR +1 more | View in SCUBA |
About the gene
| Synonyms | Adrx, C10orf58, FAM213A, MGC4248, PAMM |
|---|---|
| Chromosome | 10: 80407829-80437115 |
| Predicted location | Intracellular, Membrane, Secreted |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins |
| Molecular function | Antioxidant |
Function
Involved in redox regulation of the cell. Acts as an antioxidant. Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation. May affect bone resorption and help to maintain bone mass. Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.