Microvillus actin cytoskeleton
Gene co-expression module in Enterocytes
| Category | Cytoskeletal |
|---|---|
| Genes | 7 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 2 of 14 genes have a known function matching the annotation |
Why this annotation
Actin-bundling and severing proteins of the microvilli (VIL1, SCIN) co-occur with enterocyte metabolic enzymes (HSD17B11, CYB5A, SMPD3, PRXL2A). This defines a general enterocyte brush-border structural identity shared with the absorptive neighbors.
Genes
CYB5A, HSD17B11, PRXL2A, SCIN, SMPD3, TDP2, VIL1
Most correlated modules
- Villus-tip enterocyte transport · correlation 0.90
- Colonocyte Solute Transport · correlation 0.89
- Enterocyte lipid metabolism · correlation 0.89
- Brush-border nutrient uptake · correlation 0.88
- Gluconeogenesis/fructose metabolism · correlation 0.86
- Brush-border Nutrient Uptake · correlation 0.84
- Mature enterocyte differentiation · correlation 0.82
- Amino acid absorption · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.