Septin Cytoskeleton
Gene co-expression module in Lymphatic endothelial
| Category | Cytoskeletal |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
The top hub genes are SEPTIN2, SEPTIN7, and SEPTIN10 — three members of the septin family of cytoskeletal GTPases that form filaments and rings involved in cytokinesis, cell polarity, and membrane compartmentalization. AHNAK is a large scaffold protein associated with the cytoskeleton and membrane. DSP (desmoplakin) links intermediate filaments to desmosomes. GOLGB1 is a Golgi matrix protein. TPR is a nuclear pore scaffold. EFCAB14 is a cytoskeletal-associated calcium-binding protein. The septin triad dominates this module, making it a septin cytoskeleton program. Neighbor context: this module is distinct from the vascular identity modules, likely representing a cytoskeletal organization program in lymphatic endothelium.
Genes
AHNAK, DSP, EFCAB14, GOLGB1, PRXL2A, SEPTIN10, SEPTIN2, SEPTIN7, TPR, TTC3
Most correlated modules
- Innate Immune Activation · correlation 0.84
- Endothelial Identity · correlation 0.82
- Integrin Focal Adhesion · correlation 0.81
- Lymphatic Specification · correlation 0.81
- Vascular Lumen Formation · correlation 0.79
- ER-Lysosomal Processing · correlation 0.79
- Anticoagulant Barrier · correlation 0.76
- Lymphatic Vascular Stability · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.