RORB — RAR related orphan receptor B
RORB belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RORB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | OSR1+ Deep Fibroblast Developmental | EMCN, EPHA3, HS3ST6, ID4, OMG, OSR1, PCLO, PPP1R1B +5 more | View in SCUBA |
| Hematopoietic progenitor cells | ILC2-like State Lymphcyte development | CELSR1, CRYBG3, DIPK1C, DOK5, FAT3, KLRB1, PRL, UNC13C |
About the gene
| Synonyms | NR1F2, ROR-BETA, RZRB |
|---|---|
| Chromosome | 9: 74497335-74693177 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Nuclear receptors, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, Developmental protein, DNA-binding, Receptor |
| Biological process | Biological rhythms, Sensory transduction, Transcription, Transcription regulation, Vision |
Function
Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity (By similarity). Isoform 1 is critical for hindlimb motor control and for the differentiation of amacrine and horizontal cells in the retina. Regulates the expression of PTF1A synergistically with FOXN4 (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.