OSR1+ Deep Fibroblast
Gene co-expression module in Fibroblasts
| Category | Developmental |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes OSR1 (odd-skipped related 1, marks a specific deep submucosal intestinal fibroblast population), RORB (nuclear receptor expressed in specific stromal subsets), PCLO (piccolo scaffold), SLITRK4 and SYT1 (synaptic/neural-associated), EPHA3 (ephrin receptor), ID4 (inhibitor of differentiation), PTN (pleiotrophin, growth factor), and TCF7L2 (Wnt transcription factor) define a specialized fibroblast subtype. OSR1 is a well-established marker of a deep intestinal fibroblast subset. The neural-associated genes (PCLO, SYT1, SLITRK4) may reflect a neural-crest-like or telocyte-adjacent identity. Strongly downregulated in both UC and CD inflammation. EMCN is endothelial but expression is uniform, likely co-expressed in this fibroblast subset.
Genes
EMCN, EPHA3, HS3ST6, ID4, OMG, OSR1, PCLO, PPP1R1B, PTN, RORB, SLITRK4, SYT1, TCF7L2, ZFP36L2
Most correlated modules
- Subepithelial Fibroblast Identity · correlation 0.79
- Elastin-Fibronectin ECM · correlation 0.71
- Quiescent Stromal Identity · correlation 0.71
- Subepithelial Fibroblast · correlation 0.70
- Stromal Niche Signaling · correlation 0.56
- Wnt-niche Fibroblast · correlation 0.52
- Quiescent Anti-inflammatory Fibroblast · correlation 0.42
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.