KLRB1 — Killer cell lectin like receptor B1
KLRB1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KLRB1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Tc17 program Tc17 program | ABI3, ABRACL, CAPG, CCDC85B, FKBP11, GPR34, IL17A, NFKBIA +4 more | View in SCUBA |
| Hematopoietic progenitor cells | ILC2-like State Lymphcyte development | CELSR1, CRYBG3, DIPK1C, DOK5, FAT3, PRL, RORB, UNC13C | |
| Innate lymphoid cells | Protein Biogenesis & Import Protein processing & ER | ANAPC16, ATP6AP2, CD164, COMMD6, EEF1D, NACA, PFDN5, S100A4 +6 more | View in SCUBA |
| Mucosal-associated invariant T cell | TGF-beta Response Immune regulation | ABCA1, ARL4C, ARRDC2, CD48, DDX47, DNLZ, ERGIC1, FMNL1 +21 more | |
| Natural Killer cells | ILC1/NK Cytotoxic Cytotoxicity | A1BG, CASK, CLDND1, EIF3G, GZMK, ITM2C, NCF1, PDCD4 +4 more | View in SCUBA |
About the gene
| Synonyms | CD161, CLEC5B, hNKR-P1A, NKR, NKR-P1, NKR-P1A |
|---|---|
| Chromosome | 12: 9594551-9607916 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | CD markers, Predicted membrane proteins |
| Molecular function | Receptor |
Function
Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N- acetyllactosamine epitope. Also binds to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.