ID4 — Inhibitor of DNA binding 4
ID4 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ID4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | OSR1+ Deep Fibroblast Developmental | EMCN, EPHA3, HS3ST6, OMG, OSR1, PCLO, PPP1R1B, PTN +5 more | View in SCUBA |
| Glial cells | Glial Progenitor Identity Development | DLX2, ID2, IER5L, MARCKSL1, MYLIP, RGS2, SNAI1 | View in SCUBA |
| Pericytes | Cytokine Inflammatory Response Inflammatory | ADAMTS4, C11orf96, CEBPB, CEBPD, GEM, KCNE4, PHLDA1, RGS16 +4 more | View in SCUBA |
| Smooth muscle cells | STAT3 transcriptional program Activation | DDX3X, FAM210B, HLA-E, HNRNPH1, ITPR1, NOLC1, RAB21, STAT3 +2 more | View in SCUBA |
About the gene
| Synonyms | bHLHb27 |
|---|---|
| Chromosome | 6: 19837370-19842197 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Molecular function | Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.