DOK5 — Docking protein 5
DOK5 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DOK5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | TGF-beta Response ECM remodeling | C1orf21, CBR3, CNRIP1, FREM1, GUSB, HTRA1, LRRN4CL, NR3C1 +7 more | View in SCUBA |
| Hematopoietic progenitor cells | ILC2-like State Lymphcyte development | CELSR1, CRYBG3, DIPK1C, FAT3, KLRB1, PRL, RORB, UNC13C |
About the gene
| Synonyms | C20orf180, dJ805C22.1 |
|---|---|
| Chromosome | 20: 54475593-54651169 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.