ILC2-like State
Gene co-expression module in Hematopoietic progenitor cells
| Category | Lymphcyte development |
|---|---|
| Genes | 9 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 2 of 9 genes have a known function matching the annotation |
Why this annotation
This module has very low mean expression (0.010) and only 0.5% positive cells, suggesting a very rare cell state or possible ambient/dropout noise. PRL (prolactin) is the top hub gene — highly unusual in HPC; it may reflect rare contaminating pituitary/lactotroph signal or a spurious correlation. KLRB1 (CD161) marks ILC2/NK cells; RORB is expressed in ILC2 and some lymphoid subsets; CELSR1 and FAT3 are planar cell polarity cadherins with some neural/rare immune expression. UNC13C is a synaptic vesicle gene. The biological coherence is low despite the 'strong' module metric. In the context of the lymphocyte-heavy neighborhood, KLRB1+RORB suggest ILC2 but PRL and neural genes make this a mixed/uncertain module. Classified as ILC2-like given the dominant immune markers, but with low certainty.
Genes
CELSR1, CRYBG3, DIPK1C, DOK5, FAT3, KLRB1, PRL, RORB, UNC13C
Most correlated modules
- Regulatory T-cell State · correlation 0.71
- Naive B Cell · correlation 0.54
- T/NK Cell Identity · correlation 0.53
- Lymphoid Progenitor Commitment · correlation 0.47
- Lymphocyte Signaling · correlation 0.45
- Glucocorticoid Response · correlation 0.42
- ILC3/γδT Priming · correlation 0.42
- Lymphoid Progenitor TFs · correlation 0.42
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.