SEMA3E — Semaphorin 3E
SEMA3E belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SEMA3E's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | COL13A1+ Deep Fibroblast ECM production | APOC1, BMPER, COL13A1, CSF1, GPR63, GPX3, GRIA3, HAAO +6 more | View in SCUBA |
About the gene
| Synonyms | coll-5, KIAA0331, M-SemaK, SEMAH |
|---|---|
| Chromosome | 7: 83363238-83649139 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Human disease related genes, Predicted secreted proteins |
| Molecular function | Developmental protein |
| Biological process | Angiogenesis, Differentiation, Neurogenesis |
Function
Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.