SH2D4A — SH2 domain containing 4A
SH2D4A belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SH2D4A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Monocytes | M2 Macrophage Polarization Innate immunity | AHNAK, CRTAP, F13A1, GLDN, GSN, IDH1, IL13RA1, LDHB +7 more | View in SCUBA |
About the gene
| Synonyms | FLJ20967, PPP1R38, SH2A |
|---|---|
| Chromosome | 8: 19313693-19396218 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T- cell development and function.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.