GSN — Gelsolin

GSN belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

GSN's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Tissue-resident memory B B cell maturation	CALHM2, CCR1, CMTM7, FCRL4, FGD4, ITGB7, PIK3R6, PLD4 +4 more	View in SCUBA
Endothelial	Venous Endothelial Identity Endothelial cell development	ACE, ADARB1, CDC42EP1, CLSTN1, EMCN, FLT1, GALNT18, GPRC5B +11 more	View in SCUBA
Enterocytes	Surface colonocyte transport Absorption	CA4, CD46, CITED1, CLCN1, DOCK4, HSPB1, ITM2C, LYPD8 +4 more	View in SCUBA
Fibroblasts	Quiescent Stromal Identity Developmental	ADH1B, CXCL12, FXYD1, GSTM5, METTL7A, NFIA, PLAC9, SELENOP +1 more	View in SCUBA
Glial cells	Glial Myelination Identity Myelination	AP1S2, CALM2, CD81, CD9, COMT, GPM6B, IGFBP7, LGALS1 +6 more	View in SCUBA
Innate lymphoid cells	Actin Cytoskeletal Regulation Cytoskeleton & motility	AQP3, CCDC57, CLPTM1, COTL1, DCAF11, GYG1, MZT2B, NAA38 +7 more	View in SCUBA
Lymphatic endothelial	Innate Immune Activation Immune regulation	CD46, CLTC, CRIM1, EIF2AK2, ENSA, FEZ2, PDLIM3, PON2 +9 more	View in SCUBA
Macrophages	Oxidative Metabolic Program Mitochondrial & OxPhos	ACADM, CA2, CALM3, CAPG, COQ2, CSRP1, CSTB, DENND2D +29 more	View in SCUBA
Monocytes	M2 Macrophage Polarization Innate immunity	AHNAK, CRTAP, F13A1, GLDN, IDH1, IL13RA1, LDHB, MARVELD1 +7 more	View in SCUBA
Smooth muscle cells	Notch-TGFbeta Signaling Development	AHI1, CD81, CD9, CPED1, EDIL3, FHL1, JUND, MAF +3 more	View in SCUBA

About the gene

Synonyms	DKFZp313L0718
Chromosome	9: 121207794-121332843
Predicted location	Intracellular, Secreted
Essential gene	No
Protein class	Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Molecular function	Actin capping, Actin-binding
Biological process	Cilium biogenesis/degradation

Function

Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.