LDHB — Lactate dehydrogenase B

LDHB belongs to a gene co-expression module in 13 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

LDHB's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Oxidative Phosphorylation Mitochondrial & OxPhos	ATP5MC3, ATP5MF, ATP5PB, ATP5PF, COX5A, ELOB, ERH, NDUFA12 +8 more	View in SCUBA
CD8⁺ T cells	Ribosome Biogenesis RNA processing & translation	BTF3, CCND3, EIF3H, EIF3L, ERP29, FBL, FXYD5, LTB +8 more	View in SCUBA
Endothelial	NF-κB Oxidative Stress Stress	ACP1, ALDH7A1, ARHGDIB, CCDC85C, CDC25B, CDKN3, CMSS1, COPRS +13 more	View in SCUBA
Fibroblasts	Mitochondrial Energy Metabolism Mitochondrial & OxPhos	ATP5MC3, COX5A, COX7B, GAPDH, MDH2, NDUFA6, SLC25A3, TOMM20	View in SCUBA
Gamma-delta T cells	Glycolysis & Proteasome Housekeeping	ACAA2, ANAPC15, APEH, C1QBP, CCDC167, CHMP2A, CLNS1A, ENO1 +11 more
Glial cells	ER-Mitochondria Housekeeping Mitochondrial & OxPhos	CNN3, COX6C, HMGN3, NDUFB5, NDUFS8, PDIA3, TMBIM4, TMBIM6 +2 more	View in SCUBA
Goblet cells	Mitochondrial Chaperone Protein processing & ER	ANP32B, C1QBP, CACYBP, DEK, HSPD1, HSPE1, LSM2, PA2G4	View in SCUBA
Hematopoietic progenitor cells	Biosynthetic Housekeeping Housekeeping	BZW2, CHST12, CREG1, EEF1B2, FBL, HNRNPA1, HSP90AB1, IMPDH2 +7 more
Innate lymphoid cells	Mitochondrial OxPhos Mitochondrial & OxPhos	AKR7A2, ANXA6, AP2M1, ARL6IP4, ARPC1B, ATP5MC2, ATP5PB, BSG +21 more	View in SCUBA
Macrophages	Mitotic Spindle Assembly Cell cycle	ACTL6A, AKR7A2, ANP32E, BOLA3, BUB3, CCDC167, CENPW, CENPX +34 more	View in SCUBA
Monocytes	M2 Macrophage Polarization Innate immunity	AHNAK, CRTAP, F13A1, GLDN, GSN, IDH1, IL13RA1, MARVELD1 +7 more	View in SCUBA
Mucosal-associated invariant T cell	Cytotoxic Lymphocyte Program cytotoxicity	ANXA11, CDKN2D, CYB5A, EMP3, ETHE1, FLT3LG, GLIPR2, LTB +9 more
Natural Killer cells	Immunoproteasome Activation Inflammation	EIF5A, PDIA6, PPIA, PSMB3, PSMB8, PSMB9, PSME1, PSME2	View in SCUBA

About the gene

Chromosome	12: 21635342-21757857
Predicted location	Intracellular
Essential gene	No
Protein class	Disease related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Molecular function	Oxidoreductase

Function

Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+)

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.