M2 Macrophage Polarization
Gene co-expression module in Monocytes
| Category | Innate immunity |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 16 genes have a known function matching the annotation |
Why this annotation
Key hub genes IL13RA1 (IL-13 receptor alpha 1, canonical M2 polarization marker), F13A1 (coagulation factor XIII A1, well-established M2/alternatively activated macrophage marker), MS4A6A (monocyte/macrophage surface marker enriched in M2), RNASE6 (antimicrobial RNase expressed in monocytes), PLD3 (lysosomal phospholipase D), GSN (gelsolin, actin remodeling in phagocytes), SERPINF1 (PEDF, anti-angiogenic/anti-inflammatory), and PLXND1 (semaphorin receptor involved in monocyte migration) collectively define an M2/alternatively activated macrophage state. Increased with inflammation and decreased with remission is consistent with compensatory anti-inflammatory macrophage recruitment. Neighbor M40 shares the M2 theme with complementary scavenger receptor genes.
Genes
AHNAK, CRTAP, F13A1, GLDN, GSN, IDH1, IL13RA1, LDHB, MARVELD1, MS4A6A, PLD3, PLXND1, RNASE6, SERPINF1, SH2D4A, UACA
Most correlated modules
- Tissue-Resident Macrophage · correlation 0.82
- IL-18 Inflammasome Response · correlation 0.79
- Tissue-Resident Macrophage · correlation 0.66
- Stress-Adapted Macrophage · correlation 0.66
- Glucocorticoid Response · correlation 0.64
- Efferocytosis Tissue Macrophage · correlation 0.63
- M2 Macrophage Polarization · correlation 0.58
- Monocyte Identity · correlation 0.57
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.