IL13RA1 — Interleukin 13 receptor subunit alpha 1
IL13RA1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IL13RA1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | IL-13/STAT6 Signaling Inflammation | ABLIM1, ARL2BP, ASRGL1, ATP8B1, BMP1, BMPR2, CLIP1, CMIP +18 more | View in SCUBA |
| Enterocytes | Epithelial junction polarity Migration & adhesion | CXADR, FRMD3, KIF3B, MARVELD3, NEDD9, PTPRD, RAB6A, SLC41A2 +5 more | View in SCUBA |
| Goblet cells | Mucin O-Glycosylation Mucus production & secretion | ACLY, ASPH, C9orf152, CKAP4, ESRP1, FABP2, PLPP5, RAB2A +8 more | View in SCUBA |
| Macrophages | Myeloid Differentiation Identity Developmental | ADCK2, ALOX5, ATP2C1, CCDC6, CDK6, CMTM7, DEF6, EEF2K +21 more | View in SCUBA |
| Monocytes | M2 Macrophage Polarization Innate immunity | AHNAK, CRTAP, F13A1, GLDN, GSN, IDH1, LDHB, MARVELD1 +7 more | View in SCUBA |
About the gene
| Synonyms | CD213a1, IL-13Ra, NR4 |
|---|---|
| Chromosome | X: 118727133-118794535 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | CD markers, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Receptor |
Function
Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.