SHANK2 — SH3 and multiple ankyrin repeat domains 2
SHANK2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SHANK2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | ECM Glycan Remodeling ECM remodeling | ATP1B1, CHST11, COL8A2, LIMCH1, MGAT4A, MGAT5, MMP11, MYO7A +3 more | View in SCUBA |
About the gene
| Synonyms | CORTBP1, CTTNBP1, ProSAP1, SHANK, SPANK-3 |
|---|---|
| Chromosome | 11: 70467854-71252577 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
Function
Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.