SIX5 — SIX homeobox 5
SIX5 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SIX5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | DNA Damage Response Stress | ACSL4, AKNA, ALDH4A1, ATF7IP, ATM, BAIAP2, BCL11B, BCL9 +22 more | View in SCUBA |
About the gene
| Synonyms | DMAHP |
|---|---|
| Chromosome | 19: 45764785-45769252 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, Developmental protein, DNA-binding |
| Biological process | Transcription, Transcription regulation |
Function
Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter (By similarity). Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3 (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.