SKIC3 — SKI3 subunit of superkiller complex
SKIC3 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SKIC3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Myeloid Innate Signaling Innate immunity | ADCY7, ARHGAP18, BMP2K, C3AR1, C6orf62, CD46, CD84, CLTC +34 more | View in SCUBA |
About the gene
| Synonyms | KIAA0372, SKI3, THES, TTC37 |
|---|---|
| Chromosome | 5: 95461755-95555050 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
Function
Component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality- control pathways. The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation. SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling. In the nucleus, the SKI complex associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.