ADCY7 — Adenylate cyclase 7
ADCY7 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ADCY7's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | TCR Activation Signaling TCR Signaling | ATP2B4, CYFIP2, DIAPH1, GK5, GLG1, ITGAL, NBEAL2, NFATC3 +4 more | |
| Macrophages | Myeloid Innate Signaling Innate immunity | ARHGAP18, BMP2K, C3AR1, C6orf62, CD46, CD84, CLTC, CNEP1R1 +34 more | View in SCUBA |
About the gene
| Synonyms | AC7, KIAA0037 |
|---|---|
| Chromosome | 16: 50246137-50318135 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Lyase |
| Biological process | cAMP biosynthesis |
Function
Catalyzes the formation of cAMP in response to activation of G protein-coupled receptors (Probable). Functions in signaling cascades activated namely by thrombin and sphingosine 1-phosphate and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G alpha protein with GNA13. Also, during inflammation, mediates zymosan-induced increase intracellular cAMP, leading to protein kinase A pathway activation in order to modulate innate immune responses through heterotrimeric G proteins G(12/13) (By similarity). Functions in signaling cascades activated namely by dopamine and C5 alpha chain and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G protein with G beta:gamma complex. Functions, through cAMP response regulation, to keep inflammation under control during bacterial infection by sensing the presence of serum factors, such as the bioactive lysophospholipid (LPA) that regulate LPS-induced TNF-alpha production. However, it is also required for the optimal functions of B and T cells during adaptive immune responses by regulating cAMP synthesis in both B and T cells (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.