Myeloid Innate Signaling
Gene co-expression module in Macrophages
| Category | Innate immunity |
|---|---|
| Genes | 43 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 43 genes have a known function matching the annotation |
Why this annotation
CYBB (NOX2/gp91phox) and CYBC1-neighbor genes define the phagocyte NADPH oxidase for ROS production. C3AR1 is the complement C3a receptor on macrophages. PTGS1 (COX-1) mediates prostaglandin synthesis. ADCY7 is a myeloid adenylyl cyclase. CD84 is a SLAM-family myeloid receptor. SPRED1 inhibits RAS/MAPK downstream of cytokine receptors. BMP2K modulates endocytic/signaling pathways. Together these genes reflect myeloid innate immune signaling integrating complement, ROS, and eicosanoid programs.
Genes
ADCY7, ARHGAP18, BMP2K, C3AR1, C6orf62, CD46, CD84, CLTC, CNEP1R1, CYBB, CYTH4, DNAJC10, EFCAB14, FAM91A1, GALC, GOLIM4, HPS5, KCTD12, KLHL12, KLHL8, MAN2B2, MAX, MFSD1, NBR1, NHLRC3, PLXNB2, PPP1R9B, PTGS1, RBL2, SKAP2, SKIC3, SLC25A46, SLC30A7, SPRED1, STOM, TLR4, TM6SF1, TMEM245, TOR1AIP1, TPP1, VPS41, ZBTB38, ZYG11B
Most correlated modules
- TGF-beta Signaling · correlation 0.97
- Autophagy Vesicular Trafficking · correlation 0.96
- ER Protein Quality Control · correlation 0.96
- Endosomal Membrane Trafficking · correlation 0.96
- Chromatin Transcriptional Regulation · correlation 0.95
- Retromer Endosomal Sorting · correlation 0.94
- Myeloid Differentiation Identity · correlation 0.94
- Monocyte-Mac Iron Transport · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.