SLC22A17 — Solute carrier family 22 member 17
SLC22A17 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SLC22A17's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Glial cells | Glial Identity Homeostasis Housekeeping | ARPC1B, CMTM5, CPQ, DDAH2, FCGRT, METRN, PON2, S100B +2 more | View in SCUBA |
About the gene
| Synonyms | BOCT, BOIT, NGALR |
|---|---|
| Chromosome | 14: 23346314-23352912 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins, Transporters |
| Molecular function | Receptor |
| Biological process | Ion transport, Iron transport, Transport |
Function
Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo- 24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.